M.Sc. Courses:
Basic Biochemistry: Basic chemistry of biological materials, thermodynamics of biological systems; concept of free energy, entropy, enthalpy, free energy changes, high energy molecules; acids, bases, pH and buffers, biochemistry of macromolecules-carbohydrates, amino acids and lipids; Structure, constituents and function of biomembranes; Enzyme kinetics and mechanisms, coenzymes, cofactors, inhibitors, catalytic enzymes, ribozymes; Michaelis-Menten equation; Nucleic acidsclassification, occurrence, nucleoside, nucleotides, structures of ribosyl and deoxyribosyl nucleotides & functions; glycolysis, anaerobic oxidation of glucose, citric acid cycle; mitochondrion and bioenergetics; lipid metabolism & diseases; metabolism of amino acids, anabolism and catabolism, urea cycle, biosynthesis of proteins, purine and pyrimidine metabolism. Introduction to clinical biochemistry of GI tract, liver, cardiovascular system, endocrine functions.
Pharmacology & Therapeutics: i) Molecular basis of biological therapeutics; ii) Molecular Targets of therapeutics: Microbial targets, Signal Transduction Pathways, Autoimmune Disease Targets, Cancer Targets, Epigenetic modifications and Emerging Targets; iii) Biomarkers; iv) Chemical and Synthetic therapeutics drugs and classes; v) Peptide Therapeutics: Monoclonal Antibodies; Pharmacodynamics: i) definition, general mechanisms; ii) receptors and specificity; iii) agonists and antagonists; iv) pharmacodynamics of individual classes of drugs; v) site (or sites) of drug action (ex: narcotic analgesics); vi) specific mechanism of drug action: (a) therapeutic and side. effects. Posology: i) definition; ii) dose – response relationship; iii) potency and ED 50 (effective dose 50); minimal effective concentration; iv) efficacy: time – response graph; onset of action; duration of action; termination of action Toxicology and Applied Pharmacology: i) Mechanisms of toxicity; ii) Therapeutic Index (TI), Lethal dose 50 (LD 50); iii) Dose response complexities and adverse drug effects v) Mechanisms of Detoxification and Testing. Pharmacokinetics: i) importance of pharmacokinetics, pharmacodynamics, and pharmacometrics in the understanding of drug action, therapy, design, development, and evaluation; ii) definition and factors determining the active concentration of drug; iii) Mechanisms of drug absorption: Dissolution, epithelial barriers, active, passive transport and diffusion, Bioavailability; iv) Clinical Trials. Medicinal Plants: i) Fundamentals of Phytotherapy; ii) Classes of Medicinal Plants; iii) Chemistry and mechanisms of medicinal plant products.
Pre-Ph.D. Courses:
CM601: Concepts and perspective of molecular medicine: Basic biochemistry, molecular biology and genetics relevant to Molecular Medicine. Human genome: implication and applications. Single Nucleotide Polymorphism. Gene therapy as a potential tool to cure human diseases. Recombinant molecules in medicine. Transgenic and knock out animal models. Stem cell research and its application in human health. Intellectual property right issues and ELSI (Evaluation of the Ethical, Legal and Social Implications program).
CM-615: Biology of cancer: Overview of hallmark of cancer, mutagens carcinogens, and mutations, Tumor viruses and discovery of oncogenes activation. Role of growth factors and eceptors carcinogenesis, RAS signalling in cancer, Familial cancer syndromes and the discovery of tumor suppressor. Biomarkers, Epigenetics of cancer. Cell cycle control and the pRb tumor suppressor. Apoptosis and the p53 tumor suppressor, cellular senescence, Telomers, cellular immortalization, and the tumorigenesis, cancer stem cells, DNA repair mechanisms, Angiogenesis, Metastasis,Treatment-traditional chemotherapies, radiotherapy, immunotherapy, targeted therapy, cellular effectsof radiation- Effectof ionizing and non-ioninzing radiation on cells. DNA chromosomes and membrane, cell survival, division delay and cell cycle check points. Applications of new technologies in prevention, assessing risk, diagnostics and treatment.
CM612: Pharmacology and Therapeutics: An introductory Overview, Structure and Relationship for Pharmacophore Identification, Transmembrane Signal Mechanism, Efficacy of drug, ADME, Toxicology of drug, Pharmacokinetics, Pharmacodynamics, Drug metabolism, Biomarkers, Epigenetic Modifications and Emerging targets, Epigenetic effects in Humans, Epigenetics of Microoganism, Therapeutics, Chemical and Synthetic Therapeutic Drugs and Classes, Tumors : Weakened mitotic checkpoint, Biostatistics, Chemotherapy of Parasitic and Microbial infections, Seperation Techniques, Medicinal Plants.